鍢村攪澶栫炕涓€鑸兘娌诲ソ锛屽強鏃╅€�(j矛n)琛岃(gu墨)鑼冩不鐧傦紝鑳藉浣跨柧鐥呭緱鍒版敼鍠勶紝浣嗘槸娌荤檪鎯呮硜闇€瑕佹牴鎿�(j霉)鍢村攪澶栫炕绋嬪害鍒ゆ柗銆�
鍢村攪澶栫炕鍙兘鏄敱浜庣墮榻掔敓闀风櫦(f膩)鑲插嚭鐝�(xi脿n)鐣稿舰銆佸弽闋滅瓑鍥犵礌鎵€灏�(d菐o)鑷�锛屽氨鏈夊彲鑳芥渻灏�(d菐o)鑷村槾鍞囧嚭鐝�(xi脿n)澶栫炕鎯呮硜锛岄渶瑕佸強鏅�(sh铆)鍒伴啱(y墨)闄㈠仛鎷嶇墖妾㈡煡锛屽彲浠ラ€氶亷浣╂埓閲戝爆閶肩挡鍥哄畾鐗欏鎴栬€呮槸闅卞舰鐗欏鏂瑰紡渚嗘敼鍠勭櫏鐙€锛屽繀瑕佹檪(sh铆)鍊欎篃鍙互閫氶亷姝ｉ牅鎵嬭(sh霉)鏂瑰紡渚嗘不鐧�銆�
鍦ㄦ鏈熼枔鎮ｈ€呬竴瀹氳鍋氬ソ灞€閮ㄨ(h霉)鐞嗗伐浣�锛屼繚鎸佸眬閮ㄨ(w猫i)鐢熸竻娼�锛屽湪鐭檪(sh铆)闁撳収(n猫i)閬垮厤鍚冧竴浜涙补鐐告垨鑰呮槸鍒烘縺鎬ч鐗�锛屼互鍏嶅奖闊垮埌鎭㈠京(f霉)銆�
鍖呴牠甯傜鍥涢啱(y墨)闄�
璧ゅ嘲甯傜浜岄啱(y墨)闄�
澶師甯備汉姘戦啱(y墨)闄�
澶師甯傜浜屼汉姘戦啱(y墨)闄�
灞辫タ鐪佺叅鐐腑蹇冮啱(y墨)闄�
澶у悓甯傜浜屼汉姘戦啱(y墨)闄�
澶у悓甯傜涓€浜烘皯閱�(y墨)闄�
閫氶伡甯傜鐖炬瞾鍗€(q奴)绗竴浜烘皯閱�(y墨)闄�
鍖呴牠甯傜鍏啱(y墨)闄�
瀵у煄绺ｄ腑蹇冮啱(y墨)闄�
娴锋媺鐖惧崁(q奴)绗竴浜烘皯閱�(y墨)闄�
鍖椾含鍦嬮啱(y墨)鍫備腑閱�(y墨)闄�
鍖椾含甯傛捣娣€閱�(y墨)闄�
鍖椾含甯傜鍏啱(y墨)闄�
鍖椾含璞愯嚭閱�(y墨)闄�
鍖椾含甯傞爢缇╁崁(q奴)閱�(y墨)闄�
鍖椾含鐭虫櫙灞遍啱(y墨)闄�
鍖椾含甯傛捣娣€鍗€(q奴)濠﹀辜淇濆仴闄�
鍖椾含甯備粊鍜岄啱(y墨)闄�
鍖椾含甯傚ぇ鑸堝崁(q奴)浜烘皯閱�(y墨)闄�
娓呰彲澶у(xu茅)鐜夋硥閱�(y墨)闄�
鍖椾含甯傚欢鎱跺崁(q奴)閱�(y墨)闄�
鍖椾含甯傞殕绂忛啱(y墨)闄�
鍖椾含甯傛櫘浠侀啱(y墨)闄�
涓湅涓啱(y墨)绉戝(xu茅)闄㈠唬瀹夐杸閱�(y墨)闄㈠崡鍗€(q奴)
鍖椾含甯傞€氬窞鍗€(q奴)濠﹀辜淇濆仴闄�
鍖椾含甯傞杸闋簼鍗€(q奴)閱�(y墨)闄�
鍖椾含甯傛槍骞冲崁(q奴)涓啱(y墨)閱�(y墨)闄�
涓湅鑸┖宸ユキ(y猫)涓績閱�(y墨)闄�
鍖椾含涓啱(y墨)钘ュぇ瀛�(xu茅)鏉辩洿闁€閱�(y墨)闄㈤€氬窞闄㈠崁(q奴)
閬╃敤浜庝績閫�(j矛n)灞€閮ㄨ娑插惊鐠�(hu谩n)銆佽紨鍔╂秷鐐庛€佹秷鑵拰姝㈢棝銆傞仼鐢ㄤ簬灏嶉牳妞庣梾銆佽偐鍛ㄧ値銆侀璩�(zh矛)澧炵敓銆佽叞妞庨枔鐩ょ獊鍑恒€侀棞(gu膩n)绡€(ji茅)鐐�銆佽倢绾栫董鐐庛€佽粺绲勭箶鎵尗鍌�銆佹€ユ€ц叞鑲屽嫗鎼嶇殑杓斿姪娌荤檪銆傞仼鐢ㄤ簬绶╄В鑵块儴闂�(gu膩n)绡€(ji茅)銆佽倢鑲夌柤鐥涘強鑲遍澶栦笂楂佺値寮曡捣鐨勯棞(gu膩n)绡€(ji茅)婊戣啘鐐庢墍鑷翠箣鐤肩棝銆�
閹�(zh猫n)鍜筹紝绁涚棸锛屽钩鍠橈紝娑堢値銆傜敤浜庡挸鍠樺強鎱㈡€ф敮姘ｇ鐐庡挸鍡�銆�
1.鍘熺櫦(f膩)鎬ч珮鑶藉浐閱囪鐧ユ湰鍝佷綔鐐洪２椋熸帶鍒朵互澶栫殑杓斿姪娌荤檪,鍙柈鐛�(d煤)鎴栬垏HMG-CoA閭勫師閰舵姂鍒�(浠栨眬椤�)鑱�(li谩n)鍚堟噳(y墨ng)鐢ㄤ簬娌荤檪鍘熺櫦(f膩)鎬�(闆滃悎瀛愬鏃忔€ф垨闈炲鏃忔€�)楂樿喗鍥洪唶琛€鐧ワ紝鍙檷浣庣附鑶藉浐閱�(TC)銆佷綆瀵嗗害鑴傝泲鐧借喗鍥洪唶(LDL-C)銆佽級鑴傝泲鐧紹(ApoB)銆� 2.绱斿悎瀛愬鏃忔€ч珮鑶藉浐閱囪鐧�(HoFH)鏈搧鑸囦粬姹€椤炶伅(li谩n)鍚堟噳(y墨ng)鐢�锛屽彲浣滅偤鍏朵粬闄嶈剛娌荤檪鐨勮紨鍔╃檪娉�(濡侺DL-C琛€婕垮垎闆㈢疆鎻涙硶)锛屾垨鍦ㄥ叾浠栭檷鑴傛不鐧傜劇鏁堟檪(sh铆)鐢ㄤ簬闄嶄綆HoFH鎮ｈ€呯殑TC鍜孡DL-C姘村钩銆� 3.绱斿悎瀛愯胺鐢鹃唶琛€鐧�(鎴栨鐗╃斁閱囪鐧�)鏈搧浣滅偤椋查鎺у埗浠ュ鐨勮紨鍔╂不鐧傦紝鐢ㄤ簬闄嶄綆绱斿悎瀛愬鏃忔€ц胺鐢鹃唶琛€鐧ユ偅鑰呯殑璋风斁閱囧拰妞嶇墿鐢鹃唶姘村钩銆�
瑗垮湴閭ｉ潪閬╃敤浜庢不鐧傚媰璧峰姛鑳介殰绀�銆�
1.瀛ｇ瘈(ji茅)鎬ч亷鏁忔€ч蓟鐐庨仼鐢ㄤ簬绶╄В鎴愪汉鍜�6姝插強6姝蹭互涓婂勾榻″厭绔ョ殑瀛ｇ瘈(ji茅)鎬ч亷鏁忔€ч蓟鐐庣浉闂�(gu膩n)鐨勭櫏鐙€锛屽鎵撳櫞鍤忥紝娴侀蓟娑�锛岄蓟銆佽叚銆佸枆閮ㄧ櫦(f膩)鐧€€佺溂鐫涚櫦(f膩)鐧�銆佹疆婵�銆佺櫦(f膩)绱呫€� 2.鎱㈡€х壒鐧�(f膩)鎬ц晛楹荤柟閬╃敤浜庢不鐧傛垚浜哄拰6姝插強6姝蹭互涓婂勾榻″厭绔ョ殑鎱㈡€х壒鐧�(f膩)鎬ц晛楹荤柟鐨勭毊鑶氱櫏鐙€锛岃兘澶犻’钁楁笡杓曠槞鐧㈠拰棰�(f膿ng)鍦�(tu谩n)鐨勬暩(sh霉)閲�銆�
寤ｆ澅缇呮诞灞卞湅钘ヨ偂浠芥湁闄愬叕鍙告槸涓€瀹跺緸浜嬭棩鍝佺敓鐢�(ch菐n),钘ュ搧缍�(j墨ng)鐕�,涓崏钘ユ敹璩肩瓑妤�(y猫)鍕�(w霉)鐨勫叕鍙�锛屾垚绔嬩簬2008骞�12鏈�24鏃�锛屽叕鍙稿潗钀藉湪寤ｆ澅鐪侊紝瑭崇窗(x矛)鍦板潃鐐猴細鎯犲窞甯傚崥缇呯福闀峰閹�(zh猫n)寤ｆ睍鍏矾閭婂逗鎺掑伐妤�(y猫)鍗€(q奴)锛堢緟娴北钘ユキ(y猫)鍩庯級;缍�(j墨ng)鍦�
鍖椾含闊撶編钘ュ搧鏈夐檺鍏徃(浠ヤ笅绨＄ū鍖椾含闊撶編)鎴愮珛浜�1996骞�3鏈�锛屽叕鍙哥敘(ch菐n)鍝佹キ(y猫)鍕�(w霉)娑夊強鍏掔鐢�(ch菐n)鍝併€佹秷鍖栫鐢�(ch菐n)鍝�銆侀绉戠敘(ch菐n)鍝併€佹姉鎰熸煋钘ョ瓑闋�(l菒ng)鍩�锛�98%鐨勭敘(ch菐n)鍝佸湪鍦嬪収(n猫i)鎴愮敘(ch菐n)锛屼富瑕佺敘(ch菐n)鍝佹湁濯藉挭鎰�銆佹槗鍧﹂潨銆佹槗瀹夊钩銆佺編甯稿畨銆佸埄鍕�銆�
銆€銆€鐩婃櫘鐢熼泦鍦�(tu谩n)浣滅偤涓€瀹舵湁钁楀叓鍗佸骞村埗钘ョ稉(j墨ng)椹�(y脿n)鐨勬瓙娲插埗钘ラ泦鍦�(tu谩n)锛屾搧鏈�20浣欑ó涓婂競鐢�(ch菐n)鍝佸強閬嶅竷鍏ㄧ悆杩�4000鍚嶇殑鍝″伐銆傚叕鍙哥殑鐧�(f膩)灞曟埌(zh脿n)鐣ユ槸浠ヤ笁澶ф不鐧傞牁(l菒ng)鍩熷収(n猫i)鐨勯珮绉戞妧鐢�(ch菐n)鍝佺偤鍩虹(ch菙)锛屽嵆鑵槫銆佸収(n猫i)鍒嗘硨銆佺缍�(j墨ng)鑲岃倝椤炵柧鐥咃紝閫欎簺楂�
鍖椾含鍚屼粊鍫傝偂浠芥湁闄愬叕鍙稿悓浠佸爞鍒惰棩寤犳垚绔嬩簬1990骞�11鏈�21鏃ワ紝娉ㄥ唺鍦颁綅浜庡寳浜競澶ц垐鍗€(q奴)涓棞(gu膩n)鏉戠鎶€鍦掑崁(q奴)澶ц垐鐢熺墿閱�(y墨)钘ョ敘(ch菐n)妤�(y猫)鍩哄湴澶╄泊澶ц33铏�锛屾硶瀹氫唬琛ㄤ汉鐐哄嫉鏈濊彲銆傜稉(j墨ng)鐕熻寖鍦嶅寘鎷姞宸�銆佸埗閫犱腑鎴愯棩锛涘嚭绉熻睛鍏敤鎴�
杓濈憺鍦ㄤ腑鍦嬫キ(y猫)鍕�(w霉)瑕嗚搵鍏ㄥ湅300浣欏€�(g猫)鍩庡競锛屽苟鍦ㄨ彲涓婂競浜嗕簲澶ч牁(l菒ng)鍩熺殑楂樺搧璩�(zh矛)鐨勫壍(chu脿ng)鏂拌棩鐗╋紝鍖呮嫭鑵槫銆佺柅鑻�銆佹姉鎰熸煋銆佺値鐧ヨ垏鍏嶇柅銆佺綍瑕嬬梾绛夊鍊�(g猫)闋�(l菒ng)鍩熺殑铏曟柟钘ュ拰鐤嫍銆傚骞翠締锛岃紳鐟炲绲傝嚧鍔涗簬鈥滄垚鐐轰腑鍦嬮啱(y墨)鐧傝(w猫i)鐢熼珨绯婚噸瑕佺祫鎴�
